PCGF1 (polycomb group ring finger 1) is a member of the polycomb group (PcG) proteins. PcG in mammals, are divided into two polycomb repressive complexes (PRCs), and PCGF1 belongs to PRC1. It shares high homology to the other two members of PRC1 namely, Mel-18 and Bmi-1. This protein predominantly resides in the nucleus. It has a RING finger domain in its N-terminal, and is ubiquitously expressed in adult tissues. This gene maps to human chromosome 2p13, and spans around 400kb.
Synonyms: Anti-NSPc1; Anti-Nervous system Polycomb-1; Anti-Polycomb group RING finger protein 1; Anti-RING finger protein 68
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: PCGF1 (polycomb group ring finger 1) is involved in the repression of transcription, and is a biomarker for kidney cancer. Studies show that it promotes tumorigenesis and cell proliferation by repressing the expression of p21 through RARE (retinoid acid response element). This gene is located in the region linked to susceptibility to Parkinson's disease (PD), and therefore, it might be involved in the functional and pathological processes related to adult nervous system. In mouse, this gene is located with the locus of lethal neuromuscular wasting disorder (mnd2). It is also highly expressed in the developing nervous system, predominantly in the neural crest cells, which give rise to peripheral nervous system.
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