Poly(ADP-ribose) polymerase family member 14 (PARP14) is a nuclear protein encoded by the gene mapped to human chromosome 3q21.1. It is a member of PARP superfamily of proteins with PARP catalytic domain.
Synonyms: Anti-ARTD8; Anti-BAL2; Anti-B aggressive lymphoma protein 2; Anti-PARP-14; Anti-Poly [ADP-ribose] polymerase 14
Storage: -20C
Application: Poly(ADP-ribose) polymerase family member 14 (PARP14) has been used in immunohistochemistry and western blotting.
Biochem Physiol Actions: PARP14 (Poly ADP-ribose polymerase family, member 14) is a unique protein with its PARP domain-mediated MARylation activity. It is a member of the 18 poly-ADP ribosyl polymerase (PARP) family consisting of three macrodomains responsible for the ADP-ribosyltransferase activity. It is involved in the DNA replication mechanisms of DNA lesions and common fragile sites. The cytokine-stimulated STAT6 DNA activates the functional attributes of PARP14. It mainly stabilizes the DNA structure during replication event by minimizing the replication stress and promoting homologous recombination (HR) DNA repair. It controls various signaling pathways such as NF?B activity, B cell transcriptional regulation. It also acts as a cofactor for signal transducer and activator of transcription STAT6 activity.
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