Palmdelphin (PALMD) is an isoform of the paralemmin proteins and has 551 amino acids. It contains a conserved coiled-coil region. The gene encoding PALMD is a pro-apoptotic gene and is localized on chromosome 1p22-p21.
Synonyms: Anti-Palmdelphin; Anti-Paralemnin-like protein
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: In response to DNA damage, p53 (tumor suppressor) activates palmdelphin (PALMD) and a high concentration of PALMD is seen in the nucleus to initiate apoptosis. A decrease in PALMD expression levels leads to necroptosis-like cell death through decline in ATP. It also has a role in modulating intracellular signaling and interactions between the membrane and cytoskeleton.
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