Purinergic receptor (P2Y12) is expressed in platelets. P2Y12 is mapped to human chromosome 3q25.1. It belongs to the P2Y receptors family and is predominantly expressed in astrocytes. P2Y12 is predicted to have three ATP binding regions. It has seven transmembrane regions.
Synonyms: P2RY12 Antibody - Anti-P2RY12 antibody produced in rabbit; P2Ry12 Antibody; Anti-ADP-glucose receptor; Anti-ADPG-R; Anti-P2T(AC); Anti-P2Y purinoceptor 12; Anti-P2Y(AC); Anti-P2Y(ADP); Anti-P2Y(cyc); Anti-P2Y12; Anti-P2Y12 platelet ADP receptor; Anti-SP1999
Storage: -20C
Application: Anti-P2RY12 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: The gene P2RY12 (purinergic receptor P2Y, G-protein coupled, 12) encodes a G-protein coupled receptor for ADP and ATP coupled to G-proteins that are involved in the negative regulation of adenylyl cyclase second messenger system. It functions in normal platelet aggregation and blood coagulation. Defects in this gene may cause bleeding disorder, platelet type 8 (BDPLT8). It serves as a potential target for the treatment of thromboembolisms and other clotting disorders.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC