Outer dense fiber of sperm tails 2 (ODF2) possesses two carboxy-terminal leucine zippers. This 70-73 kDa protein is part of the sperm tail cytoskeleton and the centrosomal scaffold which associates with mother centrioles in somatic cells. The ODF2 gene is localized on human chromosome 9q34.
Synonyms: CT134; ODF84
Storage: -20C
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Biochem Physiol Actions: Outer dense fiber of sperm tails 2 (ODF2) may have a role in centrosome function. Knockout of this protein in mouse F9 embryonic carcinoma cells removes distal or subdistal appendages and inhibits primary cilium formation. Loss of ODF2 also dislocates mother centriole-specific ninein dots.
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