Synonyms: Anti-59 kDa 2'->5'-Oligoadenylate synthetase-like protein antibody produced in rabbit; Anti-TRIP-14 antibody produced in rabbit; Anti-Thyroid receptor-interacting protein 14 antibody produced in rabbit; Anti-p59 OASL antibody produced in rabbit; Anti-p59OASL antibody produced in rabbit
Storage: -20C
Application: Anti-OASL antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: OASL (2'-5'-oligoadenylate synthetase-like) is a 59kDa protein that is an atypical member of the OAS family as it does not possess the characteristic 2'-5' oligoadenylate synthetase activity. It exhibits an antiviral effect against the single-stranded RNA viruses, such as, picornavirus, encephalomyocarditis virus. It inhibits hepatitis C viral replication in vitro. OASL interacts with the transcriptional repressor Methyl CpG-binding protein 1 (MBD1) upon interferon stimulation.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC