The NSF (N-ethylmaleimide-sensitive factor) gene is mapped to human chromosome 17q21. It is a member of the AAA family and encodes a protein containing three domains, namely a SNARE-binding N-terminal domain and two ATPase domains (D1 and D2) involved in oligomerization.
Synonyms: Anti-N-Ethylmaleimide sensitive fusion protein antibody produced in rabbit; Anti-NEM-sensitive fusion protein antibody produced in rabbit; Anti-Vesicle-fusing ATPase antibody produced in rabbit; Anti-Vesicular-fusion protein NSF antibody produced in rabbit
MDL Number: MFCD02263804
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: NSF (N-ethylmaleimide-sensitive factor) gene encodes a hexameric ATPase that is involved in the dissociation of SNARE complexes that function in intracellular fusion processes. The factor also interacts with the C-terminus of GluR2 and GluR4c subunits of AMPA receptors and may function in AMPA receptor regulation.
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