Synonyms: GP91-2; MOX1; NADPH oxidase 1; NOH-1
Storage: -20C
UNSPSC Code: 12352203
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General description: NADPH oxidase 1 (NOX1) is encoded by the gene mapped to human chromosome Xq22.1. The protein belongs to the family of NADPH oxidases and is co-localized with caveolin in punctate patches on the surface and laterally on the cellular margins. NOX1 is mainly expressed in colon epithelium.
Application: Anti-NOX1 antibody produced in goat has been used for Western blotting.
Biochem/physiol Actions: NOX1 catalyzes the production of hydrogen peroxide (H2O2). Overexpression of the protein leads to the production of superoxide and H2O2 and triggers angiogenic switch, mediating vascularization and rapid expansion of the tumor. Elevated expression of NOX1 has been observed in the brain of Parkinson's disease (PD) patients.
Immunogen: Peptide with sequence C-DKATDIVTGLKQK, from the internal region of the protein sequence according toNP_008983.2; NP_39249.1
Physical form: Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
RIDADR: NONH for all modes of transport
WGK Germany: 2