Nucleolar protein 2 (NOP2) is encoded by the gene mapped to human chromosome 12p. NOP2 is a 120kDa protein. It is expressed in adult human brain and is specifically localized on a novel nucleolar microfibrillar structure.
Synonyms: Anti-NOL1; Anti-NOP120; Anti-NOP2 nucleolar protein homolog (yeast); Anti-NSUN1; Anti-p120
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Nucleolar protein 2 (NOP2) might be involved in the ribosomal synthesis and the cell cycle regulation. NOP2 is used as a marker in several cancers, including breast and lung carcinomas. The encoded protein interacts with telomerase and activates cyclin D1 gene transcription and thus, play a key role in regulation of cell proliferation.
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