The gene NLRP2 (NACHT, LRR and PYD domains-containing protein 2) is mapped to human chromosome 19q13.42. It belongs to the PAN (PYRIN and NACHT domain) family. NLRP2 is strongly expressed in lungs, placenta, and thymus. It is also referred as PAN1.
Synonyms: Anti-NACHT, LRR and PYD domains-containing protein 2; Anti-Nucleotide-binding site protein 1; Anti-PYRIN domain and NACHT domain-containing protein 1; Anti-PYRIN-containing APAF1-like protein 2
Storage: -20C
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Biochem Physiol Actions: The expression of NLRP2 (NACHT, LRR and PYD domains-containing protein 2) is controlled by lipopolysaccharide (LPS) and interferons (IFNß and IFN?). In macrophages, NLRP2 inhibits activation of NF (nuclear factor)-?B and I(inhibitor)-?B kinases, and enhances caspase-1 activation and IL (Interleukin)-1ß secretion. In astrocytes, NLRP2 inflammasome, a complex containing NLRP2, ASC (adaptor protein apoptosis-speck-like protein containing a caspase recruitment domain) and caspase-1, results in processing of inflammatory caspase-1 and IL-1ß. Polymorphism in NLRP2 is associated with rheumatoid arthritis. Single nucleotide polymosrphism in NLRP2 is linked with arsenic-induced skin lesions, chromosomal damage and respiratory diseases.
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