NLRC4 (NLR family, CARD domain containing 4) is a cytoplasmic immune receptor protein associated with inflammatory responses. It is a member of the nucleotide-binding site and leucine-rich repeat (NBS-LRR) protein. It consists of ATP/GTPase-specific P-loop and Mg2+-binding site motifs. The NBs domain contains a nucleotide-binding pocket for ATP/dATP.
Synonyms: Anti-CARD12; Anti-CLAN; Anti-CLAN1; Anti-CLANA; Anti-CLANB; Anti-CLANC; Anti-CLAND; Anti-CLR2.1; Anti-NLR family, CARD domain containing 4; Anti-ipaf
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: NLRC4 (NLR family, CARD domain containing 4) is involved in the inflammatory responses. Activated NLR (NOD-like receptors) transports the caspase-1 within the inflammasome for its proteolytic activation. It converts the inactivated pro-IL-1 into active caspase by autoproteolysis. This multiprotein caspase-1 generates several innate immune sensors such as interleukin-1 family cytokines (IL1FCs), followed by cytokine productions and inflammatory cell death (pyroptosis). Mutation in the NLRC4 causes an auto-inflammatory syndrome of enterocolitis and autoinflammation.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC