N-glycanase 1 (NGLY1) is a cytoplasmic peptide mapped to human chromosome 3p24.2.
Synonyms: Ngly1 Antibody; Ngly1 Antibody - Anti-NGLY1 antibody produced in rabbit; Anti-FLJ11005; Anti-N-glycanase 1; Anti-PNG1
Storage: -20C
Application: Anti-NGLY1 antibody produced in rabbit has been used in immunoblotting.
Biochem Physiol Actions: N-glycanase 1 (NGLY1) or peptide: N-glycanase acts on N-linked glycoproteins and glycopeptides and deglycosylates them, by cleaving on the ß-aspartyl glycosylamine bond. It takes part in the endoplasmic reticulum-associated degradation (ERAD) machinery. Mutation in the NGLY1 gene leading to its deficiency, directly disturbs the endoplasmic reticulum-associated degradation pathway. It is also implicated in abnormal tear production, neurological dysfunction and liver disease. Also, NGLY1 mutation is regarded as a congenital disorder and contributes to the developmental delay and hypotonia.
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