Synonyms: Anti-PTEN-like phosphatase antibody produced in rabbit; Anti-Phosphoinositide lipid phosphatase antibody produced in rabbit; Anti-Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: NDUFS3 (NADH:ubiquinone oxidoreductase core subunit S3) is a mitochondrial protein that encodes an integral subunit of the Q module of the mitochondrial respiratory complex-I. It has been reported that NDUFS3 may have impact on the development of ovarian cancer since down regulated expression has been found in carcinoma cells. Mutations in NDUFS3 accompanied by severe Complex-I deficiency causes Leigh syndrome and optic atrophy.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC