Synonyms: Anti-DRG-1 antibody produced in rabbit; Anti-Differentiation-related gene 1 protein antibody produced in rabbit; Anti-N-myc downstream-regulated gene 1 protein antibody produced in rabbit; Anti-Nickel-specific induction protein Cap43 antibody produced in rabbit; Anti-Protein NDRG1 antibody produced in rabbit; Anti-RTP antibody produced in rabbit; Anti-Reducing agents and tunicamycin-responsive protein antibody produced in rabbit; Anti-Rit42 antibody produced in rabbit
Storage: -20C
Application: Anti-NDRG1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: NDRG1 (N-myc downstream regulated 1) is a Rab4a (Ras-related protein Rab-4A) effector protein associated with cell proliferation, differentiation, and invasion. It localizes at the perinuclear recycling/sorting vesicles of Trans Golgi network. It is essentially required for the p53-dependent apoptosis. At the site of DNA damage, its elevated expression identifies the target genes required for mediating apoptosis. It also plays a major role in the recycling and stabilization of adhesion molecule E-cadherin. In endosome recycling, NDRG1 interacts with the membrane bound Rab4aGTPase. Reports show that NDRG1 acts as a biomarker in the development of Colorectal cancer (CRC).
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC