The NARS2 gene with 14 exons is mapped to human chromosome 11q14.1, encodes mitochondrial asparaginyl-tRNA synthetase enzyme, which belongs to aminoacyl-tRNA synthetase (mt-aaRS) family. The encoded protein is expressed extensively in the brain, cochlear, vestibular systems and in several human tissues.
Synonyms: Anti-AsnRS; Anti-Asparagine--tRNA ligase; Anti-Probable asparaginyl-tRNA synthetase, mitochondrial
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Mitochondrial asparaginyl-tRNA synthetase (NARS2) plays a role in charging mitochondrial tRNAs with their associated amino acids. Aberrations in the expression of NARS2 lead to nonsyndromic hearing loss and Leigh syndrome.
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