Myosin heavy chain 9 is expressed in platelets and the gene encoding it is localized on chromosome 22.
MDL Number: MFCD03455610
Storage: -20C
Application: Anti-Myosin IIA, non muscle antibody produced in rabbit has been used in:
•immunofluorescence
•immunohistochemistry
•fixed cell staining/ immunofluorescence staining
•immunoblot
•immunoprecipitation
Biochem Physiol Actions: Nonmuscle myosin II is involved in cell motility and adhesion, cytokinesis, vesicular transport, intracellular force generation and in morphogenesis during development. Its activity is regulated by light chain and possibly heavy chain phosphorylation and by association with proteins such as Mts1. Mutations in the NMHCA gene are found in several syndromes associated with megakaryocyte/platelet/leukocyte disorders. Mutations in the MYH9 gene causes a spectrum of macrothrombocytopenia disorders with neutrophil inclusions, termed as MYH9 disorders.