Myosin VB (MYO5B) gene spanning 372,296 bases on genomic DNA with 42 exons is mapped to human chromosome 18q21.1. The gene codes for ubiquitously expressed myosin Vb protein. MYO5B contains N-terminal motor domain and C-terminal cargo-binding domain.
Synonyms: Anti-Kiaa1119; Anti-Myosin vb
Storage: -20C
Application: Anti-MYO5B antibody produced in rabbit has been used in immunostaining and western blot analysis.
Biochem Physiol Actions: Myosin VB (MYO5B) acts as a motor for actin dependent organelle trafficking. Mutation or loss of MYO5B gene is associated with the development of an autosomal recessive syndrome, microvillus inclusion disease (MVID). Decreased expression of the protein has been observed in patients of gastric cancer. Therefore, MYO5B might act as a potential biomarker for gastric cancer. MYO5B interacts with Ras-related proteins 8a and 11a (Rab8a-Rab11a) component and stimulates stretch-induced exocytosis in bladder umbrella cells.
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