The gene MUC13 (mucin 13) is mapped to human chromosome 3q21. The gene encodes a transmembrane O-linked glycoprotein. Low levels of MUC13 are present in the epithelium of gastrointestinal, respiratory and reproductive tracts. The protein is predicted to have a tandem repeat domain, three epidermal growth factor like (EGFI-III) domains, a sea urchin sperm protein enterokinase arginine (SEA) domain, a transmembrane domain and a cytoplasmic tail.
Synonyms: Anti-DRCC1; Anti-Mucin 13, Cell Surface Associated
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: MUC13 is associated with the proliferation, migration or invasion of cancer cells. It is upregulated in epithelial tumor cells, gastric, colonic, pancreatic and ovarian cancers.
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