Synonyms: Anti-Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2; Anti-NMDMC
Storage: -20C
Application: Anti-MTHFD2 antibody produced in rabbit is suitable for western blotting at a concentration of 1.25mug/ml.
Biochem Physiol Actions: MTHFD2 encodes a mitochondrial bifunctional enzyme methylenetetrahydrofolate dehydrogenase/cyclohydrolase with NAD-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase domain. Decrease in MTHFD2 expression leads to impairment of cell migration and invasion into extracellular matrix and reduces the cell fraction with a high CD44 expression. It facilitates the regulation of breast cancer cell migration and invasion.