The gene MS4A1 (membrane spanning 4-domains A1) is also referred to as CD20 and is expressed on the surface of human B lymphocytes and to some extent on a small subset of T cells. The 33 to 35kDa, nonglycosylated protein has 4 membrane-spanning domains with both the amino and carboxy termini of the protein localized to the cytoplasm. The gene is mapped to human chromosome 11q12-13.
Synonyms: Anti-B-lymphocyte antigen CD20; Anti-B-lymphocyte surface antigen B1; Anti-Bp35; Anti-Leu-16; Anti-Membrane-spanning 4-domains subfamily A member 1
Storage: -20C
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Biochem Physiol Actions: The gene MS4A1 (membrane spanning 4-domains A1) encodes a protein belonging to the membrane-spanning 4A gene family that participates in the development and cell cycle progression in B-cells. It has been found to interact with proteins, such as transmembrane adapter protein p75/80, CD40, and major histocompatibility complex class II proteins (MHC II). It may participate in Ca2+ influx across plasma membranes, maintenance of Ca2+ concentration, and activation of B-cells. The MS4A1 protein activates Src leading to rapid phosphorylation of phospholipase C-?1 (PLC-?1) and PLC-?2, in turn activating caspase-3 signaling of apoptosis.
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