Mannose receptor, C type 1 (MRC1) is a trans-membrane glycoprotein, that is expressed at high levels in the M2 macrophages. This functional gene has 30 exons and is of 101.74 kb. MRC1 consists of a ricin b-type lectin domain (RICIN), a fibronectin type-II domain (FN2), 8 C-type lectin-like domains (CTLDs), a single transmembrane domain (TM) and a short cytosolic domain. It is also expressed on endothelial cells and plasma membrane. This gene is located on human chromosome 10p12.
Synonyms: Anti-C-type lectin domain family 13 member D; Anti-CD206 antigen; Anti-MMR; Anti-Macrophage mannose receptor 1 precursor
Storage: -20C
Application: Anti-MRC1 antibody has been used:
•in immunofluorescence Ab staining
•in confocal microscopy
•in immunohistochemical staining
Biochem Physiol Actions: Mannose receptor, C type 1 (MRC1) is involved in phagocytosis.
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