The gene mixed lineage kinase domain-like protein (MLKL) is mapped to human chromosome 16q23. Activated MLKL is localized on the cell membrane.
Synonyms: Mixed lineage kinase domain-like protein; Mlkl
Storage: -20C
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Western Blotting (1 paper)
Biochem Physiol Actions: Mixed lineage kinase domain-like protein (MLKL) primarily causes receptor-interacting protein (RIP) kinase-dependent necroptosis. However, during hepatitis, it results in programmed hepatocellular necrosis which is independent of RIPK3. MLKL also participates in endosomal trafficking and in the formation of extracellular vesicles.