Synonyms: Anti-JMJD3; Anti-JmjC domain-containing protein 3; Anti-Jumonji domain-containing protein 3; Anti-KIAA0346
Storage: -20C
UNSPSC Code: 12352203
General description: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Immunogen: JMJD3 (NP_001017426, 959-998)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of mouse JMJD3.
Physical form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: nwg