Storage: 2-8C
UNSPSC Code: 12352203
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General description: Immunoglobulin G (IgG) consists of a +¦ heavy chain in the constant (C) region. The monomeric 150kDa structure of IgG constitutes two identical heavy chains and two identical light chains with molecular weight of 50kDa and 25kDa, respectively. It belongs to the immunoglobulin family and is a widely expressed serum antibody. Disulfide bonds link the two heavy chains, the heavy and light chains and also links residues inside the chains. Maternal IgG is the only antibody transported across the placenta to the fetus. It passively immunizes the infants. IgG is further subdivided into four classes namely, IgG1, IgG2, IgG3, and IgG4 with different heavy chains, named +¦1, +¦2, +¦3, and +¦4, respectively. IgG2 is involved in immune responses to bacterial capsular polysaccharide antigens. Its deficiency has been linked to an increased susceptibility to bacterial infections.
Immunogen: Mouse IgG2a heavy chain
Physical form: Supplied in 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 10 mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free
Physical properties: Antibody format: IgG
Reconstitution: Reconstitute with 1.0 mL deionized water (or equivalent).
Specificity: This product was prepared from monospecific antiserum by immunoaffinity chromatography using Mouse antigens coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against Anti-Biotin, Anti-Rabbit Serum, Mouse IgG and Mouse Serum. Specificity was confirmed by ELISA. Typically less than 1% cross reactivity was observed against other Mouse heavy chain isotypes.
RIDADR: NONH for all modes of transport
WGK Germany: 3
Symbol: GHS06, GHS09
Signal Word: Danger
Hazard Statements: H302-H311-H411
Precautionary statements: P280-P301 + P312 + P330-P302 + P352 + P312