Matrix metalloproteinase 2 (MMP2) belong to the homologous matrix metalloproteinase (MMP) family. It consists of a homologous cysteine-switch and zinc binding regions. It is synthesized by proliferating skin fibroblasts, specific bronchial epithelial cells, and SV40-transformed lung fibroblasts.
Synonyms: Anti-72 kDa gelatinase antibody produced in rabbit; Anti-72 kDa type IV collagenase precursor antibody produced in rabbit; Anti-Gelatinase A antibody produced in rabbit; Anti-MMP-2 antibody produced in rabbit; Anti-Matrix metalloproteinase-2 antibody produced in rabbit; Anti-TBE-1 antibody produced in rabbit
MDL Number: MFCD02178885
Storage: -20C
Application: Anti-MMP2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: MMP2 (matrix metalloproteinase 2) is involved in cleaving triple helical type I and type IV collagen as well as degradation of denatured collagens. Mutation of MMP2 enzymatic activity in the serum or fibroblasts leads to the multicentric osteolysis and arthritis syndrome.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC