Mannosyl-(a-1, 3)-glycoprotein-ß-1, 2-N-acetylglucosaminyltransferase (MGAT1) gene is mapped to human chromosome 5q35. It codes for a 445 amino acid transmembrane protein with a luminal catalytic domain, localized to the medial compartment of the Golgi apparatus.MGAT1 gene is a housekeeping gene. It is expressed as two RNA transcripts, smaller one of 2.7-3.0kb and larger of 3.1kb. Both are expressed in heart, lung, skeletal muscle and pancreas. However, only larger transcript is present in the brain.
Synonyms: Anti-Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Anti-GNT-I; Anti-GlcNAc-T I; Anti-N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: MGAT1 (mannosyl-(a-1, 3)-glycoprotein-ß-1, 2-N-acetylglucosaminyltransferase 1) catalyzes the first step in the conversion of oligomannose to N-glycans. Members of MGAT enzyme family play a vital role in dietary fat absorption. Cell surface proteins, N-glycosylated by MGAT1, assist in cell-cell interactions and binding of cytokines and various other factors to the outer plasma membrane. MGAT1 gene is found to be significantly associated with body weight among women .
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