Mesoderm-specific transcript homolog protein (MEST) is a protein product of an imprinted MEST/PEG1 gene located on the chromosome that is expressed from the parental allele in majority of cell lines and foetal tissues. The gene is transcribed from two promoters: the transcript from promoter P1 is derived from both parental alleles, and the transcript from P2 is solely from the paternal allele.
Synonyms: Anti-Mesoderm-specific transcript homolog protein antibody produced in rabbit; Anti-Paternally-expressed gene 1 protein antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Mesoderm-specific transcript homolog protein (MEST) remains unmethylated at all subsequent post-pubertal stages of spermatogenesis, including mature spermatozoa. Methylation imprint is inherited from the parents and erased in the male germ line at an early foetal stage. The paternal-specific imprint is re-established later, during spermatogonial differentiation in the adult testis.
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