Synonyms: Malic enzyme 2, nad(+)-dependent, mitochondrial
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: ME2 (malic enzyme 2) is responsible for the conversion of malate to pyruvate. Recessively inherited inactivation of this gene might indirectly result in suppressed synthesis of the neurotransmitter ?-aminobutyric acid (GABA), as this enzyme is the source of pyruvate for GABA. It is also thought to catalyze the ultimate conversion of malate to citrate. In post-mortem brains of patients with psychotic or manic disorders, such as schizophreni and bipolar disorders, the expression of this protein is 5.6-times lower in anterior cingulate tissue. It plays an essential role in tumorigenesis, and its inactivation leads to suppressed tumor cell proliferation and enhanced apoptosis.
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