UIC2 is a mouse monoclonal antibody directed against the extracellular conformational epitope of P-glycoprotein (Pgp). This antibody can be used in flow cytometry, immunofluorescence microscopy and immunohistochemistry in frozen and paraffin sections to detect Pgp expression on the membrane of MDR1 positive cells. In functional experiments, UIC2 was shown to inhibit Pgp-mediated efflux activity and potentiate the cytotoxic effects of chemotherapy drugs transported by Pgp. Additionally, the UIC2 monoclonal antibody can be used in combination with MDR1 substrates for simulatenaeous detection of Pgp expression and function by flow cytometry (MILLIPORE's UIC2 Shift assay - see product ECM905).
Synonyms: P-glycoprotein, CD243, p170, Pgp, MAB4334
Application: Research Sub CategoryToxicology & Drug Resistance
Legal Information: Sepharose is a registered trademark of Cytiva
Other Notes: Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.