Microspherule protein 1 (MCRS1) is a nucleolar protein and also acts as an oncogene. The gene is located on human chromosome 12q13.
Synonyms: Anti-Icp22bp; Anti-Ino80q; Anti-Mcrs2; Anti-Microspherule protein 1; Anti-Msp58; Anti-P78
Storage: -20C
Application: Anti-MCRS1 antibody produced in rabbit has been used in immunohistochemistry.
Biochem Physiol Actions: Microspherule protein 1 (MCRS1) contributes to several cellular processes, such as growth, migration, senescence and transformation. It is overexpressed in non-small cell lung cancer (NSCLC) and enhances the growth of cancerous cells. It suppresses telomerase activity by blocking transcriptional element-interacting factor (TEIF)-mediated transactivation of the hTERT (telomerase reverse transcriptase) promoter. The protein plays a critical role in the proliferation and apoptosis of hepatocellular carcinoma (HCC) cells.
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