LUC7L3 (LUC7-like 3 pre-mRNA splicing factor) is a novel nuclear protein localized in the nucleus, with speckled distribution. It is mapped to human chromosome 17q21.33. LUC7L3 is widely expressed with highest expression seen in fetal tissues and adult brain. The protein contains two zinc finger motifs and an extended C-terminal domain rich in arginine, serine and glutamate.
Synonyms: Anti-AC005921.3-1 antibody produced in rabbit; Anti-CRE-associated protein 1; Anti-CREAP-1; Anti-Cisplatin resistance-associated overexpressed protein; Anti-Luc7A; Anti-Okadaic acid-inducible phosphoprotein OA48-18; Anti-cAMP regulatory element-associated protein 1
Storage: -20C
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Biochem Physiol Actions: LUC7L3 (LUC7-like 3 pre-mRNA splicing factor) is a U1 snRNP-associated splicing factor mainly associated with pre-mRNA splicing activity. It plays a major role in in the regulation of cardiac sodium channel splicing. Its first zinc finger motif couples with the pre-mRNA and provides guidance to the LUC7L3 splicing activity. The second zinc finger motif connects pre-mRNA to the U1 snRNP. Angiotensin II and hypoxia, contributing signals for heart failure, upregulate LUC7L3 and RBM25 (RNA-binding protein 25). LUC7L3 along with RBM25 increase cardiac sodium channel SCN5A (Sodium channel protein type 5 subunit a) splice variants. This decreases the cardiac voltage-gated Na+ current.
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