LSM14A mRNA processing body assembly factor protein homolog A (LSM14A) is a 463 amino acid protein belonging to the LSm family of proteins. It has a molecular weight of 50.5kDa and contains an amino-terminal and two carboxyl-terminal RGG-rich domains. The gene encoding LSM14A is localized on human chromosomes 19.
Synonyms: Anti-alpha-SNBP; Anti-alpha-Synuclein-binding protein, putative; Anti-FAM61A; Anti-LSM14 protein homolog A; Anti-SCD6 protein homolog
Storage: -20C
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Biochem Physiol Actions: LSM14A mRNA processing body assembly factor protein homolog A (LSM14A) is one of the components of mRNA processing bodies (P-bodies) and stress granules in cells. It may function as a shuttle for damaged mRNAs which are present in stress granules. They are transported by LSM14A to the P-bodies for degradation. Studies have shown that LSM14A binds to viral RNA or DNA and induces the activation of interferon ß (IFN-ß).
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