Lipin 1 (LPIN1) gene with 19 exons is mapped to human chromosome 2p25.1. The encoded protein contains 890 amino acids and is mainly expressed in skeletal muscles and adipose tissue. In humans and mice, LPIN1 exists in three isoforms, namely lipin-1a, ß, and?. LPIN1 belongs to the family of phosphatidic acid (PA) phosphohydrolases.
Synonyms: Anti-KIAA0188; Anti-Lipin 1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Lipin 1 (LPIN1) catalyzes the dephosphorylation of phosphatidic acid to diacylglycerol (DAG), which is a precursor of triglycerides. The encoded protein has been implicated in adipogenesis, abdominal obesity, insulin resistance and hypertriglyceridemia. Mutation in the gene is linked to rhabdomyolysis (RM), a disease characterized by skeletal muscle damage leading to myoglobinuria and acute renal failure. In addition, variation in the gene expression is also associated with hypertension and blood pressure.
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