LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase) gene is localized to human chromosome 10. This protein was initially isolated from swine brain. The mRNA is present in brain, kidney and liver.
Synonyms: Anti-NP_071409.2; Anti-phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Storage: -20C
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Biochem Physiol Actions: LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase) catalyzes the hydrolysis of P-N bonds in phosphohistidine and phospholysine. It also catalyzes the hydrolysis of P-N or P-O bonds in imidodiphosphate and pyrophosphate, respectively, but with lesser efficiency. Studies in Utah and Ashkenazi populations show that single nucleotide polymorphisms (SNPs) in this gene are associated with MDD (major depressive disorder). Its interaction with the gene HTR1A (5-hydroxytryptamine (serotonin) receptor 1A) is suggested to play a part in the pathogenesis of MDD. Up-regulation of this protein is linked with hyperthyroidism.
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