Leucine-rich repeat containing G protein-coupled receptor 5 (LGR5) is a seven-transmembrane G-protein coupled receptor. It belongs to the family of glycoprotein hormone receptor family. LGR5 is present in the endometrium layer. The LGR5 gene is located on human chromosome location 12q21.1.
Synonyms: LGR5 Antibody - Anti-LGR5 antibody produced in rabbit; Lgr5 Antibody; Anti-G-protein coupled receptor 49; Anti-G-protein coupled receptor 67; Anti-Leucine-rich repeat-containing G-protein coupled receptor 5 precursor; Anti-Orphan G-protein coupled receptor HG38
Storage: -20C
Application: Anti-LGR5 antibody produced in rabbit has been used in:
•immunocytochemistry
•immunohistochemistry
•western blotting
Biochem Physiol Actions: Leucine-rich repeat containing G protein-coupled receptor 5 (LGR5) binds to R-spondin and enhances the Wnt/ ß-catenin pathway. It stimulates tumor progression and induces colorectal cancer development. Lgr5 acts as a potential stem cell marker in numerous adult tissues. It has clinicopathological significance in various cancers, like colon, stomach, liver and esophagus. Elevated expression of LGR5 is associated with ovarian, colon and hepatocellular cancers.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC