Synonyms: Anti-beta-Galactoside-binding lectin L-14-I antibody produced in rabbit; Anti-14 kDa lectin antibody produced in rabbit; Anti-Galaptin antibody produced in rabbit; Anti-Galectin-1 antibody produced in rabbit; Anti-HBL antibody produced in rabbit; Anti-HPL antibody produced in rabbit; Anti-Lactose-binding lectin 1 antibody produced in rabbit; Anti-Lectin galactoside-binding soluble 1 antibody produced in rabbit; Anti-Putative MAPK-activating protein MP12 antibody produced in rabbit; Anti-S-Lac lectin 1 antibody produced in rabbit
Storage: -20C
Application: Anti-LGALS1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Galectin-1 (also known as GBP, GAL1) is a protein encoded by the LGALS1 gene in humans. It is a member of a family of multifunctional lectins, plays key roles in diverse biological processes that includes cell signaling, immunomodulation, neuroprotection and angiogenesis. It modulates tumor progression by mediating cell-cell and cell-extracellular matrix interactions, as well as angiogenesis and tumor immune-escape. The gene is associated with nasopharyngeal carcinoma (NPC), also contributes to both tumorigenesis and cisplatin resistance in epithelial ovarian cancer (EOC). Gal-1 is considered as a potential therapeutic target for EOC.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC