Synonyms: Anti-H-warts; Anti-Large tumor suppressor homolog 1; Anti-Serine/threonine-protein kinase LATS1; Anti-WARTS; Anti-WARTS protein kinase
Storage: -20C
UNSPSC Code: 12352203
General description: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Immunogen: LATS1 (NP_004681, 1-30)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human LATS1.
Physical form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: nwg