The gene LATS1 (large tumor suppressor kinase 1) is mapped to human chromosome 6q25.1. It is part of the Hippo pathway, which plays a role in organ size control.
Synonyms: Anti-BX276089.1; Anti-BX276089.2; Anti-Serine/threonine-protein kinase LATS1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: LATS1 (large tumor suppressor kinase 1) is a serine/threonine kinase. In the Hippo pathway, LATS1 regulates vascular invasiveness of cancer cells. In non-invasive cancer cells, absence of LATS1 results in the invasive phenotype. LATS1 along with LATS2 also controls centrosomal integrity, chromosome arrangement and cytokinesis during mitosis.
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