LAMP5 (lysosomal-associated membrane protein family) is a transmembrane glycosylated protein. It is a member of LAMP family and expressed in the cortical neurons of particular layers. In humans, the expression has been reported in the endoplasmic reticulum-golgi intermediate compartment (ERGIC) of leukemia cells.
Synonyms: Anti-BAD-LAMP; Anti-C20orf103; Anti-UNC-43; Anti-dJ1119D9.3
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: LAMP5 (lysosomal-associated membrane protein family) acts as a novel biomarker to identify leukemic human plasmacytoid dendritic cells (pDCs) in tissues and blood. The cytoplasmic tail of LAMP consists of endosomal and lysosomal addressing signal along with several conserved cysteine residues. The tail portion directly interacts with, or modified by, molecules that promote its sorting away from lysosomes. The cysteine residues form structural loops known as 'LAMP folds'.
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