Afadin is a multidomain protein that binds F-actin and E-catenin proteins at cell-cell adheren junctions. I-afadin is a ubiquitously expressed splice variant of afadin that contains PDZ and F-actin binding domains at the C-terminal end. I-afadin is homologous to the human AF-6 protein .
MDL Number: MFCD03455360
Storage: -20C
Application: Anti-l-Afadin antibody produced in rabbit has been used in:
•western blotting
•immunofluorescence experiments
•immunocytochemistry
•immunohistochemistry
Biochem Physiol Actions: AF-6/Afadin regulates the formation of tight and adherens junctions in the cell and its absence in mice leads to embryonic defects and lethality . Afadin is implicated in primary breast cancer and pancreatic cancer. It downregulates the process of migration and metastasis in cancer cells.