Lysine-specific demethylase 6A (KDM6A) is a tumor suppressor gene mapped to human chromosome Xp11.3. The gene codes for histone H3 lysine 27 (H3K27) demethylase, which is a member of the switch/sucrose non-fermentable (SWI/SNF) family.
Synonyms: Anti-UTX; Anti-Ubiquitously transcribed TPR protein on the X chromosome; Anti-Ubiquitously transcribed X chromosome tetratricopeptide repeat protein
Storage: -20C
Application: ANTI-KDM6A antibody produced in rabbit has been used in western blotting and immunoprecipitation.
Biochem Physiol Actions: Lysine-specific demethylase 6A (KDM6A) counteracts zeste homolog 2 (EZH2) function and induces tumor suppression by stimulating gene transcription of E-cadherin, cell cycle regulators and tumor-suppressing subchromosomal transferable fragments. It also eliminates trimethylation marks from histone 3 lysine 27 (H3K27) and supports histone demethylase activity through its catalytic JmjC domain. Mutation in the gene leads to the development of a rare congenital anomaly syndrome, Kabuki syndrome (KS).
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