KCNF1 (potassium channel, voltage gated modifier subfamily F, member 1) belongs to the family of voltage-gated Kv channels, which contains around 40 gene members. These channels are made of four subunits, and form heterotetramers with different members within this family. KCNF1 is also called Kv5.1, and acts as a modifier subunit, i.e. it is not functional on its own. It is expressed in brain, heart, liver, kidney, pancreas and skeletal muscles. This gene is localized to human chromosome 2p25, and codes for a protein which is composed of 495 amino acids.
Synonyms: Anti-Potassium voltage-gated channel subfamily F member 1; Anti-Voltage-gated potassium channel subunit Kv51; Anti-kH1
Storage: -20C
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Biochem Physiol Actions: KCNF1 (potassium channel, voltage gated modifier subfamily F, member 1) is not functional in itself, but acts as a modifier channel for Kv2 family of channels. It regulates the functionality of Kv2.1 and Kv2.1 channels. It acts as the a-subunit of Kv2.1 channel, and increases the rate of inactivation, thereby increasing neuronal excitability and the duration of action potential.
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