Synonyms: Anti-IP3 receptor isoform 3; Anti-Inositol 1,4,5-trisphosphate receptor type 3; Anti-InsP3R3; Anti-Type 3 InsP3 receptor; Anti-Type 3 inositol 1,4,5- trisphosphate receptor
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Inositol 1,4,5-trisphosphate receptor, type 3 (ITPR3) is a protein encoded by the ITPR3 gene in humans. It helps in mediating Ca2+ signaling in epithelia and regulates cellular functions such as secretion, apoptosis and cell proliferation. The gene is expressed in colon cancer and its expression level is directly related to aggressiveness of the tumor, which may reflect inhibition of apoptosis by the receptor. It has a strong association with the development of type 1 diabetes and, plays a critical role in the development of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and Graves' disease. It may act as a novel therapy for slow invasive growth of glioblastoma.
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