ITGA5 (integrin subunit a 5) is a transmembrane glycoprotein. The protein has a large extracellular domain, a single spanning transmembrane domain and a short cytoplasmic domain.
Synonyms: ITGA5 Antibody - Anti-ITGA5 antibody produced in rabbit; Itga5 Antibody; Anti-CD49e antigen) [Contains: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] antibody produced in rabbit; Anti-Fibronectin receptor subunit alpha antibody produced in rabbit; Anti-Integrin alpha-5 precursor antibody produced in rabbit; Anti-Integrin alpha-F antibody produced in rabbit; Anti-VLA-5 antibody produced in rabbit
Storage: -20C
Application: These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Broadly, integrins are associated with adhesive interactions between the trophoblast (blastocyst) and uterine epithelium at implantation. The ITGA5 (integrin subunit a 5) associates during dendritic cell (DC) trafficking with vascular-cell adhesion molecule-1 to mediate pre DC2 (Dendritic-cell) adhesion/transmigration. During normal hemopoiesis, cytokine-dependent activation of ITGA5 acceleartes the human hemopoietic cell adhesiveness.
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