Synonyms: Anti-IFN-alpha-responsive transcription factor subunit; Anti-IRF9; Anti-ISGF-3 gamma; Anti-ISGF-3gamma; Anti-ISGF3 p48 subunit; Anti-ISGF3G; Anti-Interferon regulatory factor 9; Anti-Interferon-stimulated gene factor 3 gamma; Anti-Transcriptional regulator ISGF3 subunit gamma
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: STAT-containing transcription factor, ISGF3 (interferon-stimulated gene factor 3) has two independent components, termed ISGF3a, regulatory component for interferon signaling, and ISGF3?, the DNA recognition subunit. It positively regulates the initial activation of Interferons-a-responsive genes. Activated a subunit of ISGF3 helps to regulate the ISGF3?-DNA interactions as well as stabilize the ternary complex. In nucleus, ISGF3? identifies IFN (interferon)-stimulated response element (ISRE) recognition component of the transcription factor and shows ISRE-binding specificity.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC