The gene encoding inositol polyphosphate multikinase (IPMK) enzyme is located on human chromosome 10q21.1. IPMK consists of inositol phosphate binding, nuclear localization signal, and ATP-binding kinase domain. It is a catalytically flexible enzyme and is part of intracellular signalling network.
Synonyms: Anti-Inositol polyphosphate multikinase
Storage: -20C
Application: Anti-IPMK antibody produced in rabbit may be used for the detection of IPMK protein in
•lymphoblasts by immunoprecipitation
•human adenocarcinogenic cell lines by western blotting
•in mouse 3T3 cells by western blotting
Biochem Physiol Actions: Inositol polyphosphate multikinase (IPMK) indirectly mediates mRNA transport from nucleus to cytoplasm by mediating synthesis of phosphatidylinositol levels. IPMK interacts and stabilizes tumor necrosis factor receptor in HEK293T cells.IPMK coordinates with various signaling networks. Its deletion impairs immune response signalling pathways. Knockdown of IPMK leads to imbalance in the inositol polyphosphates. IPMK binds to tumor suppressor protein and regulates transcription and cell death. Mutation in the IPMK gene results in a truncated protein with reduced kinase activity. IPMK gene deletion or RNA interference results in cell growth inhibition. IPMK is regarded as prime target for tumor suppression. Pathology of Huntington's disease is associated with IPMK protein depletion. In Alzheimer's patients, low IPMK transcript levels may play a key in neurodegeneration.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC