Integrator complex subunit 1 (UniProt Q8N201; also known as Int1) is encoded by the INTS1 (also known as KIAA1440, UNQ1821/PRO3434) gene (Gene ID 26173) in human. INTS1 is a large protein that is a component of the integrator complex that is involved in small nuclear RNAs U1 and U2 transcription and their 3'-box-dependent processing. During transcriptional regulation and in RNA processing, it directly binds to the C-terminal domain of the RNA polymerase II largest subunit. It has been reported that INTS1 is also involved in different cell support processes, such as the formation of a scaffold for the assembly of integrator complex. Developing INTS1 (-/-) mouse embryos show growth arrest at the early blastocyst stage and exhibit activated caspase-3 and caspase-7 that induce apoptosis within the inner cell mass of blastocyst.Ref.:Baillat, D et al. (2005). Cell 123, 265-276.Hata T., and Nakayama, M (2007), Biochim. Biophys. Acta 1773, 1039-1051.
Synonyms: Integrator complex subunit 1, Int1
Application: Research CategoryEpigenetics & Nuclear Function
Other Notes: Concentration: Please refer to lot specific datasheet.