Interleukin 37 (IL-37), also known as IL-1 family member 7 (IL-1F7), is an anti-inflammatory cytokine. It is encoded by the gene mapped to human chromosome 2q12-q14.1. IL-37 is a member of the IL-1 cytokine family. The protein is expressed in blood monocytes, endothelial cells, adipocytes and epithelial cells.
Synonyms: Anti-FIL1; Anti-FIL1(ZETA); Anti-FIL1Z; Anti-IL-1F7; Anti-IL-1H4; Anti-IL1F7; Anti-IL1F7
Storage: -20C
Application: Anti-IL37 antibody produced in rabbit has been used in immunohistochemistry.
Biochem Physiol Actions: Interleukin 37 (IL-37) is implicated in the suppression innate immunity and acquired immune response. IL-37 protects animals from inflammation and autoimmune diseases by inhibiting the production of pro-inflammatory cytokines and by activating macrophage and dendritic cells (DCs). It also exhibits protective action against atherosclerosis. Mutation in the gene is associated with the development of autoimmune thyroid disease (AITD) including Graves' disease (GD) and Hashimoto's thyroiditis (HT).
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