Intraflagellar transport protein 88 homolog (UniProt Q61371; also known as Polaris, Recessive polycystic kidney disease protein Tg737, Tetratricopeptide repeat protein 10, TgN(Imorpk)737Rpw, TPR repeat protein 10) is encoded by the Ift88 (also known as Tg737, Tg737Rpw, TgN737Rpw, Ttc10) gene (Gene ID 21821) in murine species. The primary cilium is a microtubule-based mechano- and chemo-sensory organelle that coordinates an array of cellular pathways during development and in tissue homeostasis, including Hedgehog (Hh), PDGFRalpha and Wnt signaling. Primary cilium is assembled and maintained via a process termed intraflagellar transport (IFT) in mammalian cells during growth arrest. Ift88/Polaris/Tg737 is a subunit of the IFT particle complex B required for the assembly of functional IFT. Defects in primary cilium assembly lead to severe developmental diseases and disorders referred to as ciliopathies. Polycystic kidney disease (PKD) is one of the first diseases identified to be linked to dysfunctional primary cilia. PKD was originally identified in the Oak Ridge Polycystic Kidney (ORPK) mouse harboring mutated Ift88 gene (Ift88orpk or Ift88Tg737NRpw). Ift88/Polaris/Tg737 is commonly used as a primary cilium marker.
Synonyms: Intraflagellar transport protein 88 homolog, Polaris, Recessive polycystic kidney disease protein Tg737, Tetratricopeptide repeat protein 10, TgN(Imorpk)737Rpw, TPR repeat protein 10
Application: Research Sub CategoryDevelopmental Signaling
Other Notes: Concentration: Please refer to lot specific datasheet.