IFNLR1 (Interferon ? receptor 1) is an orphan class II receptor chain belonging to the heterodimeric class II cytokine receptor. It is widely expressed in human cell lines and tissues.
Synonyms: Anti-CRF2-12; Anti-Cytokine receptor class-II member 12; Anti-Cytokine receptor family 2 member 12; Anti-IFN-lambda R1; Anti-IL-28R-alpha; Anti-IL-28RA; Anti-IL28RA; Anti-Interferon lambda receptor 1; Anti-Interleukin-28 receptor alpha chain precursor; Anti-Likely interleukin or cytokine receptor 2
Storage: -20C
Application: Anti-IL28RA antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: IFNLR1 (Interferon ? receptor 1) functions as a component of IFN-? protein. It forms a ligand-receptor system upon binding to interferon-?1. It actively participates in the JAK-STAT (Janus kinases-signal transducers and activators of transcription) pathway. It has been suggested that IFNLR1 polymorphism can be an effective tool for identifying early treatment failure of early hepatitis C virus (HCV) 2 treatment.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC